The recommended immunization schedules for persons aged 0 through 18 years approved by the Advisory Committee on Immunization Practices, the American Academy of Pediatrics, and the American Academy of Family Physicians.
1. Hepatitis B Vaccine (HepB). (Minimum Age: Birth)
At Birth:
Administer monovalent HepB to all newborns before hospital discharge.
If mother is hepatitis B surface antigen (HBsAg)-positive, administer HepB and 0.5 mL of hepatitis B immune globulin (HBIG) within 12 hours of birth.
If mother's HBsAg status is unknown, administer HepB within 12 hours of birth. Determine mother's HBsAg status as soon as possible and, if HBsAg-positive, administer HBIG (no later than age 1 week).
After the Birth Dose:
The HepB series should be completed with either monovalent HepB or a combination vaccine containing HepB. The second dose should be administered at age 1 or 2 months. The final dose should be administered no earlier than age 24 weeks.
Infants born to HBsAg-positive mothers should be tested for HBsAg and antibody to HBsAg (anti-HBs) after completion of at least 3 doses of the HepB series, at age 9 through 18 months (generally at the next well-child visit).
4-month Dose:
Administration of 4 doses of HepB to infants is permissible when combination vaccines containing HepB are administered after the birth dose.
2. Rotavirus Vaccine (RV). (Minimum Age: 6 Weeks)
Administer the first dose at age 6 through 14 weeks (maximum age: 14 weeks 6 days). Vaccination should not be initiated for infants aged 15 weeks or older (i.e., 15 weeks 0 days or older).
Administer the final dose in the series by age 8 months 0 days.
If Rotarix® is administered at ages 2 and 4 months, a dose at 6 months is not indicated.
3. Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine (DTaP). (Minimum Age: 6 Weeks)
The fourth dose may be administered as early as age 12 months, provided at least 6 months have elapsed since the third dose.
Administer the final dose in the series at age 4 through 6 years.
4. Haemophilus Influenzae Type B Conjugate Vaccine (Hib). (Minimum Age: 6 Weeks)
If PRP-OMP (PedvaxHIB® or Comvax® [HepB-Hib]) is administered at ages 2 and 4 months, a dose at age 6 months is not indicated.
TriHiBit® (DTaP/Hib) should not be used for doses at ages 2, 4, or 6 months but can be used as the final dose in children aged 12 months or older.
5. Pneumococcal Vaccine. (Minimum Age: 6 weeks for Pneumococcal Conjugate Vaccine [PCV]; 2 Years for Pneumococcal Polysaccharide Vaccine [PPSV])
PCV is recommended for all children aged younger than 5 years. Administer 1 dose of PCV to all healthy children aged 24 through 59 months who are not completely vaccinated for their age.
Administer PPSV to children aged 2 years or older with certain underlying medical conditions (see MMWR 2000;49[No. RR-9]), including a cochlear implant.
6. Influenza Vaccine. (Minimum age: 6 Months for Trivalent Inactivated Influenza Vaccine [TIV]; 2 Years for Live, Attenuated Influenza Vaccine [LAIV])
Administer annually to children aged 6 months through 18 years.
For healthy nonpregnant persons (i.e., those who do not have underlying medical conditions that predispose them to influenza complications) aged 2 through 49 years, either LAIV or TIV may be used.
Children receiving TIV should receive 0.25 mL if aged 6 through 35 months or 0.5 mL if aged 3 years or older.
Administer 2 doses (separated by at least 4 weeks) to children aged younger than 9 years who are receiving influenza vaccine for the first time or who were vaccinated for the first time during the previous influenza season but only received 1 dose.
7. Measles, Mumps, and Rubella Vaccine (MMR). (Minimum Age: 12 Months)
Administer the second dose at age 4 through 6 years. However, the second dose may be administered before age 4, provided at least 28 days have elapsed since the first dose.
8. Varicella Vaccine. (Minimum Age: 12 Months)
Administer the second dose at age 4 through 6 years. However, the second dose may be administered before age 4, provided at least 3 months have elapsed since the first dose.
For children aged 12 months through 12 years the minimum interval between doses is 3 months. However, if the second dose was administered at least 28 days after the first dose, it can be accepted as valid.
9. Hepatitis A Vaccine (HepA). (Minimum Age: 12 Months)
Administer to all children aged 1 year (i.e., aged 12 through 23 months). Administer 2 doses at least 6 months apart.
Children not fully vaccinated by age 2 years can be vaccinated at subsequent visits.
HepA also is recommended for children older than 1 year who live in areas where vaccination programs target older children or who are at increased risk of infection.
1. Hepatitis B Vaccine (HepB). (Minimum Age: Birth)
At Birth:
Administer monovalent HepB to all newborns before hospital discharge.
If mother is hepatitis B surface antigen (HBsAg)-positive, administer HepB and 0.5 mL of hepatitis B immune globulin (HBIG) within 12 hours of birth.
If mother's HBsAg status is unknown, administer HepB within 12 hours of birth. Determine mother's HBsAg status as soon as possible and, if HBsAg-positive, administer HBIG (no later than age 1 week).
After the Birth Dose:
The HepB series should be completed with either monovalent HepB or a combination vaccine containing HepB. The second dose should be administered at age 1 or 2 months. The final dose should be administered no earlier than age 24 weeks.
Infants born to HBsAg-positive mothers should be tested for HBsAg and antibody to HBsAg (anti-HBs) after completion of at least 3 doses of the HepB series, at age 9 through 18 months (generally at the next well-child visit).
4-month Dose:
Administration of 4 doses of HepB to infants is permissible when combination vaccines containing HepB are administered after the birth dose.
2. Rotavirus Vaccine (RV). (Minimum Age: 6 Weeks)
Administer the first dose at age 6 through 14 weeks (maximum age: 14 weeks 6 days). Vaccination should not be initiated for infants aged 15 weeks or older (i.e., 15 weeks 0 days or older).
Administer the final dose in the series by age 8 months 0 days.
If Rotarix® is administered at ages 2 and 4 months, a dose at 6 months is not indicated.
3. Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine (DTaP). (Minimum Age: 6 Weeks)
The fourth dose may be administered as early as age 12 months, provided at least 6 months have elapsed since the third dose.
Administer the final dose in the series at age 4 through 6 years.
4. Haemophilus Influenzae Type B Conjugate Vaccine (Hib). (Minimum Age: 6 Weeks)
If PRP-OMP (PedvaxHIB® or Comvax® [HepB-Hib]) is administered at ages 2 and 4 months, a dose at age 6 months is not indicated.
TriHiBit® (DTaP/Hib) should not be used for doses at ages 2, 4, or 6 months but can be used as the final dose in children aged 12 months or older.
5. Pneumococcal Vaccine. (Minimum Age: 6 weeks for Pneumococcal Conjugate Vaccine [PCV]; 2 Years for Pneumococcal Polysaccharide Vaccine [PPSV])
PCV is recommended for all children aged younger than 5 years. Administer 1 dose of PCV to all healthy children aged 24 through 59 months who are not completely vaccinated for their age.
Administer PPSV to children aged 2 years or older with certain underlying medical conditions (see MMWR 2000;49[No. RR-9]), including a cochlear implant.
6. Influenza Vaccine. (Minimum age: 6 Months for Trivalent Inactivated Influenza Vaccine [TIV]; 2 Years for Live, Attenuated Influenza Vaccine [LAIV])
Administer annually to children aged 6 months through 18 years.
For healthy nonpregnant persons (i.e., those who do not have underlying medical conditions that predispose them to influenza complications) aged 2 through 49 years, either LAIV or TIV may be used.
Children receiving TIV should receive 0.25 mL if aged 6 through 35 months or 0.5 mL if aged 3 years or older.
Administer 2 doses (separated by at least 4 weeks) to children aged younger than 9 years who are receiving influenza vaccine for the first time or who were vaccinated for the first time during the previous influenza season but only received 1 dose.
7. Measles, Mumps, and Rubella Vaccine (MMR). (Minimum Age: 12 Months)
Administer the second dose at age 4 through 6 years. However, the second dose may be administered before age 4, provided at least 28 days have elapsed since the first dose.
8. Varicella Vaccine. (Minimum Age: 12 Months)
Administer the second dose at age 4 through 6 years. However, the second dose may be administered before age 4, provided at least 3 months have elapsed since the first dose.
For children aged 12 months through 12 years the minimum interval between doses is 3 months. However, if the second dose was administered at least 28 days after the first dose, it can be accepted as valid.
9. Hepatitis A Vaccine (HepA). (Minimum Age: 12 Months)
Administer to all children aged 1 year (i.e., aged 12 through 23 months). Administer 2 doses at least 6 months apart.
Children not fully vaccinated by age 2 years can be vaccinated at subsequent visits.
HepA also is recommended for children older than 1 year who live in areas where vaccination programs target older children or who are at increased risk of infection.
10. Meningococcal Vaccine. (Minimum Age: 2 Years for Meningococcal Conjugate Vaccine [MCV] and for Meningococcal Polysaccharide Vaccine [MPSV])
Administer MCV to children aged 2 through 10 years with terminal complement component deficiency, anatomic or functional asplenia, and certain other high-risk groups. Persons who received MPSV 3 or more years previously and who remain at increased risk for meningococcal disease should be revaccinated with MCV.
Administer MCV to children aged 2 through 10 years with terminal complement component deficiency, anatomic or functional asplenia, and certain other high-risk groups. Persons who received MPSV 3 or more years previously and who remain at increased risk for meningococcal disease should be revaccinated with MCV.
Recommended Immunization Schedule for Persons Aged 7 Through 18 Years
1. Tetanus and Diphtheria Toxoids and Acellular Pertussis Vaccine (Tdap). (Minimum Age: 10 Years)
Administer at age 11 or 12 years for those who have completed the recommended childhood DTP/DTaP vaccination series and have not received a tetanus and diphtheria toxoid (Td) booster dose.
Persons aged 13 through 18 years who have not received Tdap should receive a dose.
A 5-year interval from the last Td dose is encouraged when Tdap is used as a booster dose; however, a shorter interval may be used if pertussis immunity is needed.
2. Human Papillomavirus Vaccine (HPV). (Minimum Age: 9 Years)
Administer the first dose to females at age 11 or 12 years.
Administer the second dose 2 months after the first dose and the third dose 6 months after the first dose (at least 24 weeks after the first dose).
Administer the series to females at age 13 through 18 years if not previously vaccinated.
3. Meningococcal Conjugate Vaccine (MCV).
Administer at age 11 or 12 years, or at age 13 through 18 years if not previously vaccinated.
Administer to previously unvaccinated college freshmen living in a dormitory.
MCV is recommended for children aged 2 through 10 years with terminal complement component deficiency, anatomic or functional asplenia, and certain other groups at high risk. Persons who received MPSV 5 or more years previously and remain at increased risk for meningococcal disease should be revaccinated with MCV.
4. Influenza Vaccine.
Administer annually to children aged 6 months through 18 years.
For healthy nonpregnant persons (i.e., those who do not have underlying medical conditions that predispose them to influenza complications) aged 2 through 49 years, either LAIV or TIV may be used.
Administer 2 doses (separated by at least 4 weeks) to children aged younger than 9 years who are receiving influenza vaccine for the first time or who were vaccinated for the first time during the previous influenza season but only received 1 dose.
5. Pneumococcal Polysaccharide Vaccine (PPSV).
Administer to children with certain underlying medical conditions (see MMWR 1997;46[No. RR-8]), including a cochlear implant. A single revaccination should be administered to children with functional or anatomic asplenia or other immunocompromising condition after 5 years.
6. Hepatitis A Vaccine (HepA).
Administer 2 doses at least 6 months apart.
HepA is recommended for children older than 1 year who live in areas where vaccination programs target older children or who are at increased risk of infection. See MMWR 2006;55(No. RR-7).
7. Hepatitis B Vaccine (HepB).
Administer the 3-dose series to those not previously vaccinated.
A 2-dose series (separated by at least 4 months) of adult formulation Recombivax HB® is licensed for children aged 11 through 15 years.
8. Inactivated Poliovirus Vaccine (IPV).
For children who received an all-IPV or all-oral poliovirus (OPV) series, a fourth dose is not necessary if the third dose was administered at age 4 years or older.
If both OPV and IPV were administered as part of a series, a total of 4 doses should be administered, regardless of the child's current age.
9. Measles, Mumps, and Rubella Vaccine (MMR).
If not previously vaccinated, administer 2 doses or the second dose for those who have received only 1 dose, with at least 28 days between doses.
10. Varicella Vaccine.
For persons aged 7 through 18 years without evidence of immunity administer 2 doses if not previously vaccinated or the second dose if they have received only 1 dose.
For persons aged 7 through 12 years, the minimum interval between doses is 3 months. However, if the second dose was administered at least 28 days after the first dose, it can be accepted as valid.
For persons aged 13 years and older, the minimum interval between doses is 28 days.
Persons aged 13 through 18 years who have not received Tdap should receive a dose.
A 5-year interval from the last Td dose is encouraged when Tdap is used as a booster dose; however, a shorter interval may be used if pertussis immunity is needed.
2. Human Papillomavirus Vaccine (HPV). (Minimum Age: 9 Years)
Administer the first dose to females at age 11 or 12 years.
Administer the second dose 2 months after the first dose and the third dose 6 months after the first dose (at least 24 weeks after the first dose).
Administer the series to females at age 13 through 18 years if not previously vaccinated.
3. Meningococcal Conjugate Vaccine (MCV).
Administer at age 11 or 12 years, or at age 13 through 18 years if not previously vaccinated.
Administer to previously unvaccinated college freshmen living in a dormitory.
MCV is recommended for children aged 2 through 10 years with terminal complement component deficiency, anatomic or functional asplenia, and certain other groups at high risk. Persons who received MPSV 5 or more years previously and remain at increased risk for meningococcal disease should be revaccinated with MCV.
4. Influenza Vaccine.
Administer annually to children aged 6 months through 18 years.
For healthy nonpregnant persons (i.e., those who do not have underlying medical conditions that predispose them to influenza complications) aged 2 through 49 years, either LAIV or TIV may be used.
Administer 2 doses (separated by at least 4 weeks) to children aged younger than 9 years who are receiving influenza vaccine for the first time or who were vaccinated for the first time during the previous influenza season but only received 1 dose.
5. Pneumococcal Polysaccharide Vaccine (PPSV).
Administer to children with certain underlying medical conditions (see MMWR 1997;46[No. RR-8]), including a cochlear implant. A single revaccination should be administered to children with functional or anatomic asplenia or other immunocompromising condition after 5 years.
6. Hepatitis A Vaccine (HepA).
Administer 2 doses at least 6 months apart.
HepA is recommended for children older than 1 year who live in areas where vaccination programs target older children or who are at increased risk of infection. See MMWR 2006;55(No. RR-7).
7. Hepatitis B Vaccine (HepB).
Administer the 3-dose series to those not previously vaccinated.
A 2-dose series (separated by at least 4 months) of adult formulation Recombivax HB® is licensed for children aged 11 through 15 years.
8. Inactivated Poliovirus Vaccine (IPV).
For children who received an all-IPV or all-oral poliovirus (OPV) series, a fourth dose is not necessary if the third dose was administered at age 4 years or older.
If both OPV and IPV were administered as part of a series, a total of 4 doses should be administered, regardless of the child's current age.
9. Measles, Mumps, and Rubella Vaccine (MMR).
If not previously vaccinated, administer 2 doses or the second dose for those who have received only 1 dose, with at least 28 days between doses.
10. Varicella Vaccine.
For persons aged 7 through 18 years without evidence of immunity administer 2 doses if not previously vaccinated or the second dose if they have received only 1 dose.
For persons aged 7 through 12 years, the minimum interval between doses is 3 months. However, if the second dose was administered at least 28 days after the first dose, it can be accepted as valid.
For persons aged 13 years and older, the minimum interval between doses is 28 days.
Immunization Schedule for Persons Aged 4 Months Through 18 Years Who Start Late or Who are More Than 1 Month Behind
1. Hepatitis B Vaccine (HepB).
Administer the 3-dose series to those not previously vaccinated.
A 2-dose series (separated by at least 4 months) of adult formulation Recombivax HB® is licensed for children aged 11 through 15 years.
2. Rotavirus Vaccine (RV).
The maximum age for the first dose is 14 weeks 6 days. Vaccination should not be initiated for infants aged 15 weeks or older (i.e., 15 weeks 0 days or older).
Administer the final dose in the series by age 8 months 0 days.
If Rotarix® was administered for the first and second doses, a third dose is not indicated.
3. Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine (DTaP).
The fifth dose is not necessary if the fourth dose was administered at age 4 years or older.
4. Haemophilus Influenzae Type B Conjugate Vaccine (Hib).
Hib vaccine is not generally recommended for persons aged 5 years or older. No efficacy data are available on which to base a recommendation concerning use of Hib vaccine for older children and adults. However, studies suggest good immunogenicity in persons who have sickle cell disease, leukemia, or HIV infection, or who have had a splenectomy; administering 1 dose of Hib vaccine to these persons is not contraindicated.
If the first 2 doses were PRP-OMP (PedvaxHIB® or Comvax®), and administered at age 11 months or younger, the third (and final) dose should be dministered at age 12 through 15 months and at least 8 weeks after the second dose.
If the first dose was administered at age 7 through 11 months, administer 2 doses separated by 4 weeks and a final dose at age 12 through 15 months.
5. Pneumococcal Vaccine.
Administer 1 dose of pneumococcal conjugate vaccine (PCV) to all healthy children aged 24 through 59 months who have not received at least 1 dose of PCV on or after age 12 months.
For children aged 24 through 59 months with underlying medical conditions, administer 1 dose of PCV if 3 doses were received previously or administer 2 doses of PCV at least 8 weeks apart if fewer than 3 doses were received previously.
Administer pneumococcal polysaccharide vaccine (PPSV) to children aged 2 years or older with certain underlying medical conditions (see MMWR 2000;49[No. RR-9]), including a cochlear implant, at least 8 weeks after the last dose of PCV.
6. Inactivated Poliovirus Vaccine (IPV).
For children who received an all-IPV or all-oral poliovirus (OPV) series, a fourth dose is not necessary if the third dose was administered at age 4 years or older.
If both OPV and IPV were administered as part of a series, a total of 4 doses should be administered, regardless of the child's current age.
7. Measles, Mumps, and Rubella Vaccine (MMR).
Administer the second dose at age 4 through 6 years. However, the second dose may be administered before age 4, provided at least 28 days have elapsed since the first dose.
If not previously vaccinated, administer 2 doses with at least 28 days between doses.
8. Varicella Vaccine.
Administer the second dose at age 4 through 6 years. However, the second dose may be administered before age 4, provided at least 3 months have elapsed since the first dose.
For persons aged 12 months through 12 years, the minimum interval between doses is 3 months. However, if the second dose was administered at least 28 days after the first dose, it can be accepted as valid.
For persons aged 13 years and older, the minimum interval between doses is 28 days.
9. Hepatitis A Vaccine (HepA).
HepA is recommended for children older than 1 year who live in areas where vaccination programs target older children or who are at increased risk of infection. See MMWR 2006;55(No. RR-7).
10. Tetanus and Diphtheria Toxoids Vaccine (Td) and Tetanus and Diphtheriatoxoids and Acellular Pertussis Vaccine (Tdap).
Doses of DTaP are counted as part of the Td/Tdap series
Tdap should be substituted for a single dose of Td in the catch-up series or as a booster for children aged 10 through 18 years; use Td for other doses.
11. Human Papillomavirus Vaccine (HPV).
Administer the series to females at age 13 through 18 years if not previously vaccinated.
Use recommended routine dosing intervals for series catch-up (i.e., the second and third doses should be administered at 2 and 6 months after the first dose). However, the minimum interval between the first and second doses is 4 weeks. The minimum interval between the second and third doses is 12 weeks, and the third dose should be given at least 24 weeks after the first dose.
Administer the 3-dose series to those not previously vaccinated.
A 2-dose series (separated by at least 4 months) of adult formulation Recombivax HB® is licensed for children aged 11 through 15 years.
2. Rotavirus Vaccine (RV).
The maximum age for the first dose is 14 weeks 6 days. Vaccination should not be initiated for infants aged 15 weeks or older (i.e., 15 weeks 0 days or older).
Administer the final dose in the series by age 8 months 0 days.
If Rotarix® was administered for the first and second doses, a third dose is not indicated.
3. Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine (DTaP).
The fifth dose is not necessary if the fourth dose was administered at age 4 years or older.
4. Haemophilus Influenzae Type B Conjugate Vaccine (Hib).
Hib vaccine is not generally recommended for persons aged 5 years or older. No efficacy data are available on which to base a recommendation concerning use of Hib vaccine for older children and adults. However, studies suggest good immunogenicity in persons who have sickle cell disease, leukemia, or HIV infection, or who have had a splenectomy; administering 1 dose of Hib vaccine to these persons is not contraindicated.
If the first 2 doses were PRP-OMP (PedvaxHIB® or Comvax®), and administered at age 11 months or younger, the third (and final) dose should be dministered at age 12 through 15 months and at least 8 weeks after the second dose.
If the first dose was administered at age 7 through 11 months, administer 2 doses separated by 4 weeks and a final dose at age 12 through 15 months.
5. Pneumococcal Vaccine.
Administer 1 dose of pneumococcal conjugate vaccine (PCV) to all healthy children aged 24 through 59 months who have not received at least 1 dose of PCV on or after age 12 months.
For children aged 24 through 59 months with underlying medical conditions, administer 1 dose of PCV if 3 doses were received previously or administer 2 doses of PCV at least 8 weeks apart if fewer than 3 doses were received previously.
Administer pneumococcal polysaccharide vaccine (PPSV) to children aged 2 years or older with certain underlying medical conditions (see MMWR 2000;49[No. RR-9]), including a cochlear implant, at least 8 weeks after the last dose of PCV.
6. Inactivated Poliovirus Vaccine (IPV).
For children who received an all-IPV or all-oral poliovirus (OPV) series, a fourth dose is not necessary if the third dose was administered at age 4 years or older.
If both OPV and IPV were administered as part of a series, a total of 4 doses should be administered, regardless of the child's current age.
7. Measles, Mumps, and Rubella Vaccine (MMR).
Administer the second dose at age 4 through 6 years. However, the second dose may be administered before age 4, provided at least 28 days have elapsed since the first dose.
If not previously vaccinated, administer 2 doses with at least 28 days between doses.
8. Varicella Vaccine.
Administer the second dose at age 4 through 6 years. However, the second dose may be administered before age 4, provided at least 3 months have elapsed since the first dose.
For persons aged 12 months through 12 years, the minimum interval between doses is 3 months. However, if the second dose was administered at least 28 days after the first dose, it can be accepted as valid.
For persons aged 13 years and older, the minimum interval between doses is 28 days.
9. Hepatitis A Vaccine (HepA).
HepA is recommended for children older than 1 year who live in areas where vaccination programs target older children or who are at increased risk of infection. See MMWR 2006;55(No. RR-7).
10. Tetanus and Diphtheria Toxoids Vaccine (Td) and Tetanus and Diphtheriatoxoids and Acellular Pertussis Vaccine (Tdap).
Doses of DTaP are counted as part of the Td/Tdap series
Tdap should be substituted for a single dose of Td in the catch-up series or as a booster for children aged 10 through 18 years; use Td for other doses.
11. Human Papillomavirus Vaccine (HPV).
Administer the series to females at age 13 through 18 years if not previously vaccinated.
Use recommended routine dosing intervals for series catch-up (i.e., the second and third doses should be administered at 2 and 6 months after the first dose). However, the minimum interval between the first and second doses is 4 weeks. The minimum interval between the second and third doses is 12 weeks, and the third dose should be given at least 24 weeks after the first dose.
